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Definition

γ-Aminobutyric acid (GABA, C4H9NO2) is the chief inhibitory neurotransmitter in the central nervous system reducing neuronal excitability throughout the nervous system and is directly responsible for the regulation of muscle tone. Neurons that produce GABA as their output are called GABAergic neurons, and have chiefly inhibitory action at receptors.

Clinical Significance

Because of it’s inhibitory action GABA is a calming force in the central nervous system. Some would say it is the brains natural endogenous Valium! It can help put an end to worrying rumination that go around in the anxious brain. A deficit in the neurotransmitters GABA and serotonin can make it very difficult to stop worrying and down regulate the neural activity that fuels anxiety.

GABA in therapy

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 Neurotransmitters  
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